Inhoudsopgave
Wat is een afweerstoornis?
Als u een afweerstoornis heeft, werkt uw afweersysteem niet goed. Daardoor bent u gevoeliger voor infecties. Een ander woord voor afweerstoornis is immuundeficiëntie.
Is diabetes type 1 een primaire immuundeficiëntie?
Secundaire immuundeficiënties daarentegen zijn ziekten die het gevolg zijn van (veelal externe) factoren die het immuunsysteem nadelig beïnvloeden, zoals het gebruik van immuunsuppressiva of metabole ziekten als diabetes mellitus.
What are TLRs and how do they work?
TLRs signal through the recruitment of specific adaptor molecules, leading to activation of the transcription factors NF-κB and IRFs, which dictate the outcome of innate immune responses.
What are toll-like receptors (TLRs)?
Toll-Like Receptors (TLRs) play a critical role in the early innate immune response to invading pathogens by sensing microorganism and are involved in sensing endogenous danger signals. TLRs are evolutionarily conserved receptors are homologues of the Drosophila Toll protein, discovered to be important for defense against microbial infection.
Where can I find information about TLR procedures and service priorities?
For information about the TLR procedure and transmission service priorities, please refer to NERC Reliability Standard IRO-006-5 – Reliability Coordination – Transmission Loading Relief and IRO-006-EAST-2 – Transmission Loading Relief Procedure for the Eastern Interconnection. These two documents are available on the Reliability Standards page.
What is the difference between TLR2 and TLR4?
The soluble TLRs originate from enzymatic cleavage of the full-length receptor (TLR2), 14 alternative splicing of the TLR gene (TLR4), 15 or from a separate gene (TLR5). 16 Both soluble TLR2 and TLR4 reduce the response of their membrane-bound form, and thus may act as decoy receptors that prevent an excessive response to their TLR ligands.